ABSTRACT
Objective To evaluate the differential diagnostic value of IVIMGDWI in hepatocellular carcinoma (HCC)and atypical hepatic hemangioma (H H).Methods 3.0T MR images of 28 patients with HCC and atypical H H confirmed respectively by surgical or pathological diagnosis were retrospectively analyzed.3.0T MR routine and DWI multiple b value sequences were performed,and the related derivative parameters of IVIMGDWI (intravoxel incoherent motion diffusion,MRI)were obtained.GE ADW4.6 Functool automatic postGprocessing software and statistical methods were used for multiGparameters analyses,and the ROC curve was established to predict the value of the differential diagnosis.Results The values of ADC,slow diffusion coefficient (D)and perfusion fraction (PF)between HCC and atypical HH were statistically significant(P＝0.00,P＝0.021 ,P＜0.05 ),that was to say,there were significant differences in IVIMGDWI multiparameter comparisons between the HCC and atypical HH.And the value of fast diffusion coefficient (D?)was not statistically significant between HCC and atypical HH (P＝0.112,P＞0.05),that was to say,there was no significant difference in the multiparameter comparison between the HCC and atypical HH;The specificity and sensitivity of IVIMGDWI in HCC were from high to low:D (97.8%)＞ADC(97.4%)＞PF (82.9%),and the specificity and sensitivity of IVIMGDWI in atypical H H were D (9 7.1%)＞ADC (87.1%)＞PF (6 7.9%),from high to low,while D? was not statistically significant.Conclusion It is characteristic for the imaging manifestation of HCC and atypical HH with IVIMGDWI imaging,that is one of the important methods for clinical diagnosis and differential diagnosis of HCC and atypical HH.
ABSTRACT
Objective To analyze the diagnostic value of parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and dynamic contrast-enhanced MRI (DCE-MRI) in cervical cancer and to explore the correlation of parameters between DCE-MRI and IVIM-DWI.Methods MRI data of 30 patients with cervical cancer confirmed by surgical pathology and 26 patients with normal cervix confirmed by clinical or MRI examination were analyzed retrospectively.All patients underwent IVIM-DWI and DCE-MRI.The IVIM-DWI was performed to calculate the values of ADC,D,D* and f.The values of Ktrans,Kep and Ve were measured on DCE-MRI.All parameters between cervical cancer and normal cervix were compared by two independent sample t-test.Diagnostic efficacy of these parameters in cervical cancer group was evaluated by using area under curve(AUC).The correlation of these parameters between IVIM-DWI and DCE-MRI was analyzed by Pearson correlation.Results The D*,f,Ktrans,Kep and Ve in cervical cancer were significantly higher than those in normal cervix.The ADC and D in cervical cancer were significantly lower than those in normal cervix.The differences of these parameters between the two groups were statistically significant (P ＜0.05).The AUC of Ktrans was the maximum (0.958),with diagnostic sensitivity of 86.7％ and specificity of 100％.F and K were positively correlated (r=0.446,P＜0.05).F and Kep were positively correlated (r=0.400,P＜0.05).Conclusion IVIM-DWI and DCE-MRI can improve the diagnostic value of cervical cancer.DCE-MRI has better diagnostic performance than IVIM-DWI.Significantly positive correlations were found between perfusion paramenters from IVIM-DWI and quantitative perfusion paramenters from DCE-MRI.